This course introduces the emerging nano-electronic devices that can overcome the approaching end of Moore’s scaling and their applications in bio-engineering. Also, it provides a basic understanding of quantum device physics as well as the interactions between semiconductor surfaces and ion electrolytes, which can explain various device operations in nano-scale, quantum dimensions. The first half of the course covers the basics of nano-electronic device physics including the concepts of energy bands, effective mass, and holes. Then the introduction to various emerging nano-device structures will be given. The second half focuses on the practices with basic physics simulations, which can enhance the students’understanding of the quantum device physics and provide opportunities for students to design their own nano-electronic or bio-electronic devices and analyze their characteristics.